Can my Mastiff fly in-cabin?

I have a 100lb mastiff who is relocating across the country with me. I discovered recently that there's an air travel embargo on mastiffs, and they are banned from flying cargo on every airline I can find.

She is clearly too large to fly in-cabin. Do I have any other options for air travel? My only other option is to use a service such as citizen shipper where a complete stranger would drive her clear across the country for 5 days.

I DO NOT want to go that route but I'm not sure if I have any other options. Does anyone know?

You drive across the country

To answer the question in your topic headline, No, your dog can't fly in the cabin.
There are, or used to be, pet transport services that would fly pets around the country, and not in the cargo hold, but in the main cabin of a small jet.

Try looking at this site

or just use the internet to look up pet transport services.

Your dog can't fly in the cabin. There are a number of pet transport services, and I believe that some of them fly the animals in the main cabin of a plane rather than in cargo.